Spinor field realizations of the non-critical W2,4W_{2,4} string based on the linear W1,2,4W_{1,2,4} algebra

In this paper, we investigate the spinor field realizations of the $W_{2,4}$ algebra, making use of the fact that the $W_{2,4}$ algebra can be linearized through the addition of a spin-1 current. And then the nilpotent BRST charges of the spinor non-critical $W_{2,4}$ string were built with these realizations.Comment: 10 pages, no figures, revtex4 style, accepted by Commun.Theor.Phy

1/N expansion formalism for high-spin states

The 1/$N$ expansion solutions for the interacting boson model are extended to higher orders using computer algebra. The analytic results are compared with those obtained from an exact diagonalization of the Hamiltonian and are shown to be very accurate. The extended formulas for level energies and E2 transitions will be useful in the analysis of high-spin states in both normal and superdeformed nuclei.Comment: 11 pages, Latex, 3 figures available upon reques

Cost-effectiveness of rotavirus immunization in vietnam: Exploring impacts of herd immunity and patterns of breastfeedingof

OBJECTIVES: : Rotavirus is the most common cause of severe diarrhoea worldwide. This study was designed to evaluate the cost-effectiveness of rotavirus immunization in Vietnam taking into account herd immunity and patterns of breastfeeding. The affordability of implementing universal rotavirus immunization was assessed based on both GAVI-subsidized and market vaccine prices for the next 5 years from the perspective of the Vietnamese health care system. METHODS: An age-structured birth cohort model for Vietnam was developed to compare two strategies of no vaccination and universal rotavirus vaccination in 2011. A lifetime time horizon was used with monthly time cycles for those under one year and annually thereafter. The analysis was performed under three breastfeeding scenarios: 1) 100% exclusive breastfeeding for children under 6 months; 2) 100% partial breastfeeding, and 3) 100% no breastfeeding. Herd immunity was explored in all scenarios. Monte Carlo simulations were used to examine the acceptability and affordability of the immunization strategy. RESULTS: Rotavirus immunization would effectively reduce severe cases of rotavirus during the first 5 years of life. Herd immunity makes rotavirus vaccination a cost-saving strategy under the GAVI-subsidized vaccine price in the case of partial breastfeeding and a cost-effective strategy in all breastfeeding scenarios under the market vaccine price. Affordability results showed that at the GAVI-subsidized vaccine price, rotavirus vaccination is affordable. CONCLUSIONS: This is the first study in developing countries considering herd immunity under rotavirus vaccination. If the indirect effect were considered, vaccination would become a cost-saving strategy. Given the high mortality rate of diarrhea in children under-five-years of age, our findings show rotavirus immunization to be an effective and “must-do” prevention strategy. Vaccination, however, only becomes affordable if Vietnam receives GAVI's financial support. In the next five years, Vietnam will need financial support from international organizations to implement rotavirus vaccination

Cell regulation by phosphotyrosine-targeted ubiquitin ligases

Three classes of E3 ubiquitin ligases, members of the Cbl, Hakai, and SOCS-Cul5-RING ligase families, stimulate the ubiquitination of phosphotyrosine-containing proteins, including receptor and nonreceptor tyrosine kinases and their phosphorylated substrates. Because ubiquitination frequently routes proteins for degradation by the lysosome or proteasome, these E3 ligases are able to potently inhibit tyrosine kinase signaling. Their loss or mutational inactivation can contribute to cancer, autoimmunity, or endocrine disorders, such as diabetes. However, these ligases also have biological functions that are independent of their ubiquitination activity. Here we review relevant literature and then focus on more-recent developments in understanding the structures, substrates, and pathways through which the phosphotyrosine-specific ubiquitin ligases regulate diverse aspects of cell biology

SnapShot: Lysine Methylation beyond Histones

Lysine methylation is a prevalent post-translational modification (PTM) used by the cell to reversibly regulate protein function. Although it has been extensively studied in the context of histones and the associated chromatin, the remaining methyllysine proteome remains largely unexplored. This SnapShot provides an overview of the current state of lysine methylation research and its emergence as a dynamic PTM occurring on histone and non-histone proteins. Lysine methylation is a prevalent post-translational modification (PTM) used by the cell to reversibly regulate protein function. Although it has been extensively studied in the context of histones and the associated chromatin, the remaining methyllysine proteome remains largely unexplored. This SnapShot provides an overview of the current state of lysine methylation research and its emergence as a dynamic PTM occurring on histone and non-histone proteins

Experimental evidence for the interplay between individual wealth and transaction network

We conduct a market experiment with human agents in order to explore the structure of transaction networks and to study the dynamics of wealth accumulation. The experiment is carried out on our platform for 97 days with 2,095 effective participants and 16,936 times of transactions. From these data, the hybrid distribution (log-normal bulk and power-law tail) in the wealth is observed and we demonstrate that the transaction networks in our market are always scale-free and disassortative even for those with the size of the order of few hundred. We further discover that the individual wealth is correlated with its degree by a power-law function which allows us to relate the exponent of the transaction network degree distribution to the Pareto index in wealth distribution.Comment: 6 pages, 7 figure

Phosphotyrosine recognition domains: The typical, the atypical and the versatile

SH2 domains are long known prominent players in the field of phosphotyrosine recognition within signaling protein networks. However, over the years they have been joined by an increasing number of other protein domain families that can, at least with some of their members, also recognise pTyr residues in a sequence-specific context. This superfamily of pTyr recognition modules, which includes substantial fractions of the PTB domains, as well as much smaller, or even single member fractions like the HYB domain, the PKC and PKC C2 domains and RKIP, represents a fascinating, medically relevant and hence intensely studied part of the cellular signaling architecture of metazoans. Protein tyrosine phosphorylation clearly serves a plethora of functions and pTyr recognition domains are used in a similarly wide range of interaction modes, which encompass, for example, partner protein switching, tandem recognition functionalities and the interaction with catalytically active protein domains. If looked upon closely enough, virtually no pTyr recognition and regulation event is an exact mirror image of another one in the same cell. Thus, the more we learn about the biology and ultrastructural details of pTyr recognition domains, the more does it become apparent that nature cleverly combines and varies a few basic principles to generate a sheer endless number of sophisticated and highly effective recognition/regulation events that are, under normal conditions, elegantly orchestrated in time and space. This knowledge is also valuable when exploring pTyr reader domains as diagnostic tools, drug targets or therapeutic reagents to combat human diseases. © 2012 Kaneko et al.; licensee BioMed Central Ltd

Cost-effectiveness of rotavirus immunization in Vietnam:Results and challenges

OBJECTIVES: To assess the cost-effectiveness of universal rotavirus immunization, explicitly the use of Rotateq® and affordability of implementing rotavirus immunization based on the Global Alliance for Vaccines and Immunization (GAVI)-subsidized vaccine price in the context of Vietnamese health care system for the next 5 years. METHODS: An age-structured cohort model was developed for the 2009 Vietnamese birth cohort and applied a 5-year time horizon with time cycle of 1 month for <1-year-old children and annually thereafter. Results from no vaccination and vaccination were compared. Outcomes included rotavirus episodes requiring home-treatment, outpatient visits, hospitalizations and deaths. Multiple outcomes per rotavirus infection are possible in the model. Acceptability and affordability analyses were done using Monte Carlo simulations. Costs were expressed in 2009 US$. RESULTS: Rotavirus immunization would not completely protect under-five-year-old children against rotavirus infection due to partial nature of vaccine immunity, however, would effectively reduce rotavirus severe cases by ∼55$1.6 million annually. In the base-case, the incremental cost per quality- adjusted-life-year (QALY) was US$665 from health care perspective,-Vietnamese per-capita-GDP in 2009. Affordability results showed that at the GAVI-subsidized vaccine price, rotavirus vaccination could be affordable in Vietnam. CONCLUSIONS: Rotavirus immunization in Vietnam would be a cost-effective health intervention. However, it only becomes affordable under the GAVI's financial support. Vaccine price is the most crucial factor to decision-makers regarding introducing this vaccine into the country's immunization. Given the high underfive mortality rate, results showed that rotavirus immunization is the “best hope” for prevention of rotavirus-related diarrhoeal disease in Vietnam. In the next five years, Vietnam is definitely in debt to external financial support in implementing rotavirus vaccination. It is recommended that new and cheaper rotavirus vaccine candidates be developed to speed up rotavirus vaccines introduction in the developing world